Patents and Publications

Patents

Patent

Application Country

Stem Cell With Suppressed SOCS and Improved Immunosuppressive Ability and Use Thereof

Registered in US, EU, Japan

  • Method For Sorting Highly Effective Stem Cells For Treating Immune Disorder

  • Method For Selecting High-Efficacy Stem Cell By Using Downregulation In Expression Or Activity Of Socs

Registered Japan

  • Method For Sorting Highly Effective Stem Cells For Treating Immune Disorder

  • Method For Selecting High-Efficacy Stem Cell By Using Downregulation In Expression Or Activity Of Socs

Registered in US, EU, China

  • Method for the production of stem cell having enhanced efficacy and use thereof

  • Methods for Selecting Improved Stem Cell Using SOCS Inhibition

  • Methods for Selecting Improved Stem Cell Using SOCS Inhibition

  • Method for cultivating high-potency stem cells using S-I-S production

  • Composition for promoting cell engraftment comprising stem cells with enhanced efficacy

  • Method for the production of stem cell having enhanced efficacy and use thereof

Registered in Korea

  • A method for enhancing the efficacy of stem cells, their culture medium, or exosomes isolated from the culture medium

  • Manufacturing method of human-derived mesenchymal stem cell culture solution

  • Cell matrix suspension culturing method

Applied in Korea

  • S-I-S culture method for the production of stem cell having enhanced efficacy

  • Composition for promoting cell engraftment comprising stem cell having enhanced efficacy

  • Composition for anticancer comprising stem cell having enhanced efficacy

PCT International

 Registration

Publications

Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges. 

Leukemia. 2019; 33:597-611.

Involvement of TLR3-dependent PGES expression in immunosuppression by human bone marrow mesenchymal stem cells. 

Stem Cell Reviews and Reports. 2018;14:286-293.

Enhanced immunosuppressive properties of human mesenchymal stem cells primed by interferon-γ. 

EBioMedicine. 2018;28:261-273.

Cell culture density affects the stemness gene expression of adipose tissue-derived mesenchymal stem cells. 

Biomedical Reports. 2017;6:300-306.

Effect of ex vivo culture density on CXCR7 expression in human mesenchymal stem cells.

International Journal of Clinical and Experimental Medicine. 2016;9:10802-10810.

Cell culture density affects the proliferation activity of human adipose tissue stem cells. 

Cell Biochemistry and Function. 2016;34:16-24.

Strategies to improve the immunosuppressive properties of human mesenchymal stem cells. 

Stem Cell Research & Therapy. 2015;6:179.

Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density. 

PLoS One. 2014;9:e83363.

A strategy for enhancing the engraftment of human hematopoietic stem cells in NOD/SCID mice. 

Annals of Hematology. 2013;92:1595-1602.

Effect of ex vivo culture conditions on immunosuppression by human mesenchymal stem cells. 

BioMed Research International. 2013;2013:154919.

Correlation between chemokines released from umbilical cord blood-derived mesenchymal stem cells and engraftment of hematopoietic stem cells in NOD/SCID mice. 

Pediatric Hematology and Oncology. 2011;28:682-690.

Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. 

Cellular Immunology. 2009;259:150-156.