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NASH-related Cirrhosis

  • Chronic inflammation of the liver, caused by viral infection, excessive alcohol consumption, fat accumulation, or abnormal immune challenge, results in excessive deposition of extracellular matrix. This causes structural changes to the liver and a decrease in the number of hepatocytes, which concurrently leads to loss of liver function or liver cancer.

  • Liver cirrhosis is a late-stage liver disease in which healthy liver tissue is replaced with scar tissue, resulting in permanent damage to the liver. Viral infection or alcoholic hepatitis are clear causes of liver cirrhosis have a clear causes of liver cirrhosis, and so many treatments have been developed to date. In contrast, NASH-related cirrhosis, which is caused by various chronic diseases, has a complicated mechanism, and so there is currently no approved treatment other than liver transplantation.

  • Owing to changes in eating habits, the number of patients with liver cirrhosis caused by NASH is increasing rapidly worldwide.

  • To treat liver fibrosis, it is necessary to control inflammation of the liver tissue and regenerate the tissue in which fibrosis has occurred. IntenCell® is expected to act effectively in the treatment of liver fibrosis by regulating the differentiation of macrophages and dissolving excessively secreted extracellular matrix.

  • In a preclinical study, IntenCell® decreased fibrotic factors (collagen I and α-SMA) indicating activation of hepatic stellate cells and alleviated irreversible liver fibrosis in a CCl4-induced cirrhotic mouse model.

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